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AG Fiedler


Contact

PD Dr. rer. nat.

Tomas Fiedler 

  • Wissenschaftler
    am Institut für Medizinische Mikrobiologie, Virologie und Hygiene

+49 (0) 381 494 5916
+49 (0) 381 494 5795
+49 (0) 381 494 5902  

tomas.fiedler{bei}med.uni-rostock.de


Büro

Raum: 264

Universitätsmedizin Rostock
IMIKRO
Schillingallee 70
D-18057 Rostock

Sekretariat

Gudrun Riedel

  • Sekretärin
    am Institut für Medizinische Mikrobiologie, Virologie und Hygiene

+49 (0) 381 494 5919
+49 (0) 381 494 5925

gudrun.riedel{bei}med.uni-rostock.de

Raum: 112, EG

Publikationen

AG Fiedler

AG Kreikemeyer

Main Topics

Systems biology and metabolism of gram-positive cocci

In cooperation with modeller groups we aim to understand the metabolic processes enabling gram-positive homfermentative lactic acid bacteria such as Streptococcus pyogenes and Enterococcus faecalis to colonize (or invade) the human host.

We experimentally support the modelling groups in reconstructing the metabolic networks of those bacteria and construct genome-scale metabolic models.
Based on the models, we try to identify potential new drug targets interfering with metabolic processes specific and vital for the bacteria.

Virulence mechanisms of Streptococcus pyogenes

Streptococcus pyogenes is a major gram positive pathogen causing diseases ranging from mild superficial skin and throat infections (Impetigo contagiosa, pharyngitis/”strep throat”) to more severe up to life threatening infections (scarlet fever, necrotizing fasciitis, sepsis, toxic-shock-like syndrome).

Numerous virulence factors enable the bacteria to cause those diseases.
We work on the functional characterization of exo-enzymes that may play a role in S. pyogenes virulence. 

Virulence mechanisms of Tropheryma whipplei

Whipples disease (WD) is a rare but life-threatening infectious disease that is poorly understood.

While there is some knowledge on the immunological and genetic predispositions leading to susceptibility towards WD on the host side, almost nothing is known on the biology of the causative agent, the low GC gram-positive bacterium Tropheryma whipplei.
Therefore, we work on the exploration of virulence mechanisms that enable these bacteria to interact with human host cells.

Interactions between bacterial pathogens and mesenchymal stem cells

Mesenchymal stem cells are present in numerous mesodermal tissues.

Therefore, during infections bacteria encounter these cells. In a collaboration with PD Dr. Kirsten Peters (Cell Biology Group of the Rostock University Medical Centre) and Dr. Sonja Oehmcke-Hecht (IMIKRO) we investigate the impact of pathogenic bacteria and their surface structures on adipose-derived mesenchymal stem cells in terms of viability, proliferation, immunological activation, and differentiation.

Microbial enzymes in cancer therapy

Microbial enzymes converting nutrients essential for growth of tumor cells are promising candidates in cancer therapy.

In collaboration with Dr. Claudia Maletzki (Molecular Oncology and Immune Therapy group of the Rostock University Medical Centre) we work on the application of arginine-famishment of solid tumors using bacterial arginine-degrading enzymes.

Team

Group leader

PD Dr. rer. nat.

Tomas Fiedler 

  • Wissenschaftler
    am Institut für Medizinische Mikrobiologie, Virologie und Hygiene

+49 (0) 381 494 5916
+49 (0) 381 494 5795
+49 (0) 381 494 5902  

tomas.fiedler{bei}med.uni-rostock.de


Büro

Raum: 264

Universitätsmedizin Rostock
IMIKRO
Schillingallee 70
D-18057 Rostock

Sekretariat

Gudrun Riedel

  • Sekretärin
    am Institut für Medizinische Mikrobiologie, Virologie und Hygiene

+49 (0) 381 494 5919
+49 (0) 381 494 5925

gudrun.riedel{bei}med.uni-rostock.de

Raum: 112, EG

Publikationen

AG Fiedler

AG Kreikemeyer

Team

Senta Becker +49 (0) 381 494 5939
Tobias Schröder +49 (0) 381 494 5939
Christin Matzack +49 (0) 381 494 5939
Marcel Lino Dangel +49 (0) 381 494 5939
Aline Scholz +49 (0) 381 494 5939

Technical assistant

Dipl. Ing. (FH)

Yvonne Humboldt

  • Medizinisch-technische Assistentin in der Forschung
  • Sicherheitsbeauftragte am IMIKRO
  • Mitarbeiterin Kurslabor

+49 (0) 381 494 5957
+49 (0) 381 494 5795
+49 (0) 381 494 5902

yvonne.humboldt{bei}med.uni-rostock.de

Büro: 101/102, EG