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AG Fiedler


Contact

PD Dr. rer. nat. Tomas Fiedler

PD Dr. rer. nat.

Tomas Fiedler 

  • Wissenschaftler
    am Institut für Medizinische Mikrobiologie, Virologie und Hygiene

+49 (0) 381 494 5916
+49 (0) 381 494 5795
+49 (0) 381 494 5902  

tomas.fiedler{bei}med.uni-rostock.de


Büro

Raum: 264

Universitätsmedizin Rostock
IMIKRO
Schillingallee 70
D-18057 Rostock

Sekretariat

Gudrun Riedel

  • Sekretärin
    am Institut für Medizinische Mikrobiologie, Virologie und Hygiene

+49 (0) 381 494 5919
+49 (0) 381 494 5925

gudrun.riedel{bei}med.uni-rostock.de

Raum: 112, EG

Publikationen

AG Fiedler

AG Kreikemeyer

location

Anfahrt zum IMIKRO

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Main Topics

Systems biology and metabolism of gram-positive cocci

In cooperation with modeller groups we aim to understand the metabolic processes enabling gram-positive homfermentative lactic acid bacteria such as Streptococcus pyogenes and Enterococcus faecalis to colonize (or invade) the human host.

We experimentally support the modelling groups in reconstructing the metabolic networks of those bacteria and construct genome-scale metabolic models.
Based on the models, we try to identify potential new drug targets interfering with metabolic processes specific and vital for the bacteria.

Virulence mechanisms of Streptococcus pyogenes

Streptococcus pyogenes is a major gram positive pathogen causing diseases ranging from mild superficial skin and throat infections (Impetigo contagiosa, pharyngitis/”strep throat”) to more severe up to life threatening infections (scarlet fever, necrotizing fasciitis, sepsis, toxic-shock-like syndrome).

Numerous virulence factors enable the bacteria to cause those diseases.
We work on the functional characterization of exo-enzymes that may play a role in S. pyogenes virulence. 

Interactions between bacterial pathogens and mesenchymal stem cells

Mesenchymal stem cells are present in numerous mesodermal tissues.

Therefore, during infections bacteria encounter these cells. In a collaboration with PD Dr. Kirsten Peters (Cell Biology Group of the Rostock University Medical Centre) and Dr. Sonja Oehmcke-Hecht (IMIKRO) we investigate the impact of pathogenic bacteria and their surface structures on adipose-derived mesenchymal stem cells in terms of viability, proliferation, immunological activation, and differentiation.

Microbial enzymes in cancer therapy

Microbial enzymes converting nutrients essential for growth of tumor cells are promising candidates in cancer therapy.

In collaboration with Dr. Claudia Maletzki (Molecular Oncology and Immune Therapy group of the Rostock University Medical Centre) we work on the application of arginine-famishment of solid tumors using bacterial arginine-degrading enzymes.


Group

PD Dr. rer. nat.

Tomas Fiedler 

  • Wissenschaftler
    am Institut für Medizinische Mikrobiologie, Virologie und Hygiene

+49 (0) 381 494 5916
+49 (0) 381 494 5795
+49 (0) 381 494 5902  

tomas.fiedler{bei}med.uni-rostock.de


Büro

Raum: 264

Universitätsmedizin Rostock
IMIKRO
Schillingallee 70
D-18057 Rostock

Sekretariat

Gudrun Riedel

  • Sekretärin
    am Institut für Medizinische Mikrobiologie, Virologie und Hygiene

+49 (0) 381 494 5919
+49 (0) 381 494 5925

gudrun.riedel{bei}med.uni-rostock.de

Raum: 112, EG

Publikationen

AG Fiedler

AG Kreikemeyer

Dipl. Ing. (FH)

Yvonne Humboldt

  • Medizinisch-technische Assistentin in der Forschung
  • Sicherheitsbeauftragte am IMIKRO
  • Mitarbeiterin Kurslabor

+49 (0) 381 494 5957
+49 (0) 381 494 5795
+49 (0) 381 494 5902

yvonne.humboldt{bei}med.uni-rostock.de

Büro: 101/102, EG

Dipl.-Biol.

Katharina Ekat

  • Postdoc
    am Institut für Medizinische Mikrobiologie, Virologie und Hygiene

+49 (0) 381 494  5939
+49 (0) 381 494  5795
+49 (0) 381 494  5902

Büro: 120,  EG

MSc

Eric Zitzow

  • Phd-Student
    am Institut für Medizinische Mikrobiologie, Virologie und Hygiene

+49 (0) 381 494  5939
+49 (0) 381 494  5795
+49 (0) 381 494  5902

Büro: 120,  EG

Philip Eisenberg

Claudia Michaelis

Kerren Volkmar